Journal article
Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab
T Siegal, H Charbit, I Paldor, B Zelikovitch, T Canello, A Benis, ML Wong, AP Morokoff, AH Kaye, I Lavon
Journal of Neurosurgery | Published : 2016
Abstract
Objective: Bevacizumab is an antiangiogenic agent under investigation for use in patients with high-grade glioma. It produces a high rate of radiological response; however, this response should be interpreted with caution because it may reflect normalization of the tumor vasculature and not necessarily a true antitumor effect. The authors previously demonstrated that 4 hypoxia-mediated microRNAs (miRNA) - miR-210, miR-21, miR-10b, and miR-196b - are upregulated in glioma as compared with normal brain tissue. The authors hypothesized that the regulation and expression of these miRNAs would be altered in response to bevacizumab treatment. The object of this study was to perform longitudinal mo..
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Funding Acknowledgements
We thank Lucy Paradiso and Professor Kate J. Drummond from the Departments of Neurosurgery and Surgery, The Royal Melbourne Hospital and the University of Melbourne, for laboratory technical assistance and for clinical help and support related to patient management; Dr. Yigal Shoshan from the Department of Neurosurgery and Anat Mordechai and Anat Bar-Halevi from the Gaffin Center for Neuro-Oncology, Hadassah University Hospital, for their help in patient care and management, data management, and study coordination; and Neal Tsur from Hebrew University for assistance with statistics and graphic presentations. We also thank the Israel Cancer Association for the generous assistance of the ICA USA 2011 Golf Classic Proceeds, The Royal Melbourne Hospital Neuroscience Foundation, and the Brain Foundation of Australia for supporting this work.